Systematic Literature Review

Systematic Literature Review

A Systematic Literature Review (SLR) is a rigorous research tool that aims to answer a clearly formulated question through a detailed analysis of existing research. 

Here’s how we at AccuScript ensure its successful execution:

  • Design: Our SLR follows a clearly defined protocol or plan. The criteria are set before the review process starts.
  • Transparent Search: We conduct a comprehensive, transparent search using strict inclusion and exclusion criteria.
  • Resources: These searches are conducted over various electronic databases such as PubMed, Embase, MEDLINE, Web of Science, Cochrane Library, and Google Scholar.
  • Grey Literature: We also utilize grey literature to ensure a robust review.
  • Replicable and Reproducible: Our SLR processes can be replicated and reproduced by other researchers.
  • Information Focus: We critically examine and report the type of information search, focusing on a specific topic or answering a defined question.
  • Analysis: By following a predefined protocol, relevant studies are identified, selected, and analyzed. We often use statistical methods for meta-analysis.
  • Critical Appraisal: We evaluate the evidence for risk of bias using common tools such as the NICE checklist, Cochrane risk-of-bias (RoB 2), Newcastle-Ottawa scale (NOS), Joanna Briggs Institute (JBI) checklists, Drummonds, etc.

Our Expertise: Our SLR experts bring a wealth of experience in conducting literature reviews and scientific writing. To date, they have completed over 50 systematic reviews with various types of research projects. Here are a few examples:

  • Disease Research: Hematological malignancies (e.g. multiple myeloma, diffuse large B cell lymphoma, follicular lymphoma, mantle cell lymphoma, myelofibrosis), solid tumor cancer (e.g. metastatic pancreatic cancer, HNSCC, NSCLC, metastatic colorectal cancer), rheumatoid arthritis, non-tuberculosis mycobacterium infections, NASH, NAFLD.
  • Therapeutic Areas: Novel therapeutic areas like CAR T cell therapy, monoclonal antibodies, and Bi-specific antibodies.
  • Medical Devices: Devices such as Intrauterine devices (IUDs).